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The efficacy of Ozempic was investigated in five phase 3 trials in patients with type 2 diabetes who were treated with oral antidiabetic agents (OADs), either alone or in combination with basal insulin. The DURATION-1 and DURATION-5 trials included patients with type 2 diabetes receiving metformin and a stable dose of either sitagliptin or an OAD other than metformin, while the DURATION-6 and DURATION-7 trials included similar patients treated with metformin plus a sulfonylurea. The change from baseline in HbA1c at week 52 was evaluated as the primary endpoint for each trial.

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